Mifepristone 200 mg, also known as RU-486 is an oral tablet used in combination with Misoprostol for pregnancy termination (of a gestational period of 70 days or less). It blocks the effects of progesterone and stops the pregnancy from growing. It is also used to control high blood sugar levels in patients with Cushing’s syndrome. This medicine is taken orally with water. 24-36 hours after taking Mifepristone, the four tablets of Misoprostol are recommended to be taken buccally.
It should be noted that Mifepristone alone does not cause an abortion. It should be used in combination with Misoprostol (Cytotec 200 mcg) for the termination of pregnancy.
How does RU-486 (Mifepristone) 200mg work?
Mifepristone 200 mg (RU-486) is a synthetic antiprogestational steroid that blocks the activity of progesterone at the progesterone receptors and stimulates uterine contractions. It antagonizes the endometrial and myometrial effects of progesterone in women. In other words, it detaches the endometrium from the uterine wall to stop the pregnancy from progressing.
It also exhibits antiglucocorticoid activity, and thus, blocks the binding of cortisol to its receptor. Cortisol is a natural glucocorticoid that affects the blood sugar levels in the body. Mifepristone reduces the effects of excess cortisol and keeps the sugar levels in control.
Who should not take Mifepristone 200 mg?
Mifepristone 200 mg may not be suitable for you if it has been more than 10 weeks (or 70 days) since your last menstrual period, or:
- If you have an ectopic pregnancy.
- If you have an intrauterine device (IUD) in place.
- If you take blood thinners.
- If you are getting treated with corticosteroid therapy (or medications).
- If you are allergic to Mifepristone, Misoprostol, or similar drugs.
- If you have inherited porphyria.
- If you have problems with adrenal glands.