Mifepreston(ru 486) tablet

RU-486 (Mifepristone 200 mg)


  • Used in combination with Misoprostol to cause first-trimester abortion
  • Stops the pregnancy from growing
  • Softens the cervix and causes uterine contractions
  • Controls hyperglycemia in patients with Cushing’s syndrome


Mifepristone 200 mg, also known as RU-486 is an oral tablet used in combination with Misoprostol for pregnancy termination (of a gestational period of 70 days or less). It blocks the effects of progesterone and stops the pregnancy from growing. It is also used to control high blood sugar levels in patients with Cushing’s syndrome. This medicine is taken orally with water. 24-36 hours after taking Mifepristone, the four tablets of Misoprostol are recommended to be taken buccally. 

It should be noted that Mifepristone alone does not cause an abortion. It should be used in combination with Misoprostol (Cytotec 200 mcg) for the termination of pregnancy.

How does RU-486 (Mifepristone) 200mg work?

Mifepristone 200 mg (RU-486) is a synthetic antiprogestational steroid that blocks the activity of progesterone at the progesterone receptors and stimulates uterine contractions. It antagonizes the endometrial and myometrial effects of progesterone in women. In other words, it detaches the endometrium from the uterine wall to stop the pregnancy from progressing. 

It also exhibits antiglucocorticoid activity, and thus, blocks the binding of cortisol to its receptor. Cortisol is a natural glucocorticoid that affects the blood sugar levels in the body. Mifepristone reduces the effects of excess cortisol and keeps the sugar levels in control.

Who should not take Mifepristone 200 mg?

Mifepristone 200 mg may not be suitable for you if it has been more than 10 weeks (or 70 days) since your last menstrual period, or:

  1. If you have an ectopic pregnancy.
  2. If you have an intrauterine device (IUD) in place.
  3. If you take blood thinners.
  4. If you are getting treated with corticosteroid therapy (or medications).
  5. If you are allergic to Mifepristone, Misoprostol, or similar drugs.
  6. If you have inherited porphyria.
  7. If you have problems with adrenal glands.

Directions for Use

oral administration of mifepristone

For the medical termination of pregnancy, a single tablet of Mifepristone 200 mg (RU486) is recommended to be taken orally with water. 24-36 hours after consuming Mifepristone, four tablets of Misoprostol 200 mcg should be taken buccally.

For patients with Cushing’s syndrome, a starting dose of 300 mg is recommended to be taken once a day. The dose may be increased depending on the response to the medication but not more than 1200 mg in one day.  

Side Effects



Headaches are common that usually occur after taking the RU486 (Mifepristone) tablet. Getting a sound sleep and drinking water can provide relief from headaches.



Some women may experience a change in their bowel movements. Loose, watery stools may indicate symptoms of diarrhea. Keeping yourself properly hydrated can help prevent dehydration.

Menstrual Cramps


Abdominal or stomach pain or uterine cramping is a common side effect of mifepristone. Cramps are normal and expected during the treatment. Your doctor may prescribe you a pain medication to get relief from stomach pain. 



Feeling nauseated and having the urge to vomit is a common side effect of mifepristone. Your doctor may prescribe you an antiemetic drug to prevent or control nausea and vomiting.


Ans. When administering abortion pills at home, a single pill of Mifepristone 200 mg is recommended to be taken orally with water. 24-36 hours after taking Mifepristone, four pills of Misoprostol 200 mcg are recommended to be taken buccally (by placing the four pills in the cheek pouch – two pills on either side of the mouth). Make sure you’re in a comfortable place as you’ll experience heavy bleeding and cramping after taking Misoprostol. Bleeding will be heavier than your period. Keep a pack of sanitary pads handy. Your doctor may recommend you to take a tablet of Ibuprofen 400 mg an hour before taking Misoprostol to ease the pain.

Ans. RU486 or Mifepristone is dubbed as the abortion pill. RU486 is used in combination with Misoprostol to terminate an early pregnancy (of not more than 10 weeks) in women. On the other hand, Plan B (also known as the morning-after pill) is an emergency contraception that helps to prevent pregnancy. 

Ans. For the medical termination of pregnancy, both mifepristone and misoprostol are recommended to be taken to complete the abortion process. Taking only Mifepristone can result in the following:

  • A complete abortion without taking Misoprostol.
  • An incomplete abortion – meaning the products of conception do not get expelled from the uterus. 
  • Pregnancy that develops normally and doesn’t cause any fetal anomalies.

Ans. Mifepristone is slowly terminated from the system – 50% between 12 and 72 hours. It has a terminal elimination half-life of 18 hours. It gets excreted in the form of feces (83%) and urine (9%) and becomes undetectable by 11 days. 


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